Alzheimer's: Common gene explains why some drugs fail

Recent research shows that a certain gene may explain why some Alzheimer’s drugs work in certain people but may fail in others.

The gene is called CHRFAM7A, and it is specific to humans, though only 75% of people have it. It is a fusion gene, a fusion between a gene that encodes a receptor for the neurotransmitter acetylcholine, and a type of enzyme called a kinase. Acetylcholine plays a key role in memory and learning, and researchers have long linked it with the development of Alzheimer’s.

Further research is needed to understand this concept, but researchers hope this can help pave the way to more personalized approach toward treating Alzheimer’s. The findings were presented at the Alzheimer’s Association International Conference, which took place in Los Angeles, CA.

A new study helps to explain why some Alzheimer’s drugs work in some people but not in others, and why some yet may succeed in animals but not in humans.

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